G 12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation
نویسندگان
چکیده
منابع مشابه
the effect of vocabulary instruction through semantic mapping on learning and recall of efl learners
چکیده ندارد.
15 صفحه اولInhibition of autophagy enhances the anticancer activity of bortezomib in B-cell acute lymphoblastic leukemia cells.
B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging disease to treat in adults because of the high rates of relapse and refractory. Bortezomib, as a proteasome inhibitor, exerts obvious cytotoxicity against ALL cells and increases the sensitivity of ALL cells to conventional chemotherapeutic agents. We observed that bortezomib inhibited proliferation, induced apoptosis, arrested t...
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15 صفحه اولBortezomib: proteasome inhibition as an effective anticancer therapy.
VELCADER (bortezomib, Millennium Pharmaceuticals, Inc., Cambridge, MA, and Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ) is a first-in-class proteasome inhibitor developed specifically for use as an antineoplastic agent. Inhibition of the proteasome results in disruption of homeostatic mechanisms within the cell that can lead to cell death. Bortezomib's first ind...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2010
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgq097